Physiological analyses of dysphagia of sarcopenia using disease model rats

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17034
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Niigata University
• Principal Investigator: Nagoya Kouta 新潟大学, 医歯学系, 助教 (10806491)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: COPD / 嚥下 / 呼吸 / 生理学

Outline of Final Research Achievements

Chronic obstructive pulmonary disease (COPD) is a respiratory disease known as dyspnea. We previously analyzed the effects of COPD on breathing and swallowing using COPD model rats. As a result, it was found that COPD increases the frequency of swallowing during inspiration and also changes swallowing-related muscle activity.In this study, we investigated Schluckatmung (small inspiration), which is dependent on the central respiratory circuit and indicates a short inspiration prior to swallowing. In the COPD model, Schluckatmung (small inspiration) was observed, but its frequency was slight and did not show a significant increase due to the disease. It was considered that peripheral changes due to COPD may not lead to modulation of the respiratory center of the brainstem.

Free Research Field

摂食嚥下リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

疾患による生理学的影響を理解することはリハビリテーションを行う上で非常に重要である。本研究は慢性閉塞性肺疾患(COPD)による呼吸・嚥下動態の変調が肺や筋などの末梢性によるものか脳幹呼吸中枢による中枢性によるものかを検証するために解析を行った。本研究結果は、COPD罹患による呼吸・嚥下の変調は脳幹呼吸中枢によるものではなく、リハビリテーションのアプローチ先として肺や筋など末梢が有効であることを示唆している。本研究結果がCOPD患者の摂食嚥下障害患者の新たなリハビリテーション模索の一助となることを期待したい。