A study of prevention and treatment of progressive condylar resorption using a rat mandibular bone distraction model.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17085
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Suda Daisuke 新潟大学, 医歯学系, 助教 (20806137)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 進行性下顎頭吸収（PCR） / 下顎骨延長モデルラット / 卵巣摘出（OVX）ラット

Outline of Final Research Achievements

Progressive condylar resorption (PCR) refers to a disease in which the bone of the mandibular condyle is resorbed after orthognathic surgery. We have previously conducted experiments in which mechanical load was applied to the mandibular condyle using a rat mandibular traction model. In this study, we investigated the effect of parathyroid hormone (PTH) on the prevention and treatment of PCR. Because PCR has been reported to be related to female hormones, we conducted experiments using ovariectomized (OVX) rats. When the length of the mandibular condyle bone defect in OVX rats was measured after load was applied to the mandibular condyle by mandibular traction, the bone defect length was 1091 μm in the non-PTH-administered group, whereas it was smaller at 714 μm in the PTH-administered group.

Free Research Field

ライフサイエンス　外科系歯学

Academic Significance and Societal Importance of the Research Achievements

今回の実験の結果で副甲状腺ホルモン（PTH）製剤が、進行性下顎頭吸収（PCR）の予防・治療法として有用である可能性を示すことができました。今後のPCRの予防・治療法開発の一助になったものと考えます。