2022 Fiscal Year Final Research Report
The role of BMP-3b in the bone metastatic niche with breast cancer
| Project/Area Number |
21K17119
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | BMP-3b / 乳がん |
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| Outline of Final Research Achievements |
In the TGF-β superfamily-related factors, lower expression of BMP-3, BMP-2, ACVR2B, and TGF-β1 as well as BMP-3b was associated with worse mortality of breast cancer, and BMP-3b was expressed in osteoblasts. BMP-3b knockout mice increased bone mass and knockout-derived osteoblasts had high capacity of osteoblast differentiation than wild-type. In other words, BMP-3b may negatively regulate bone mass by suppressing osteogenesis of osteoblast lineage cells.
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| Free Research Field |
口腔外科学
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| Academic Significance and Societal Importance of the Research Achievements |
Medication-Related Osteonecrosis of the Jaw（MRONJ）はビスホスホネート製剤や抗RANKL抗体などの骨吸収抑制薬使用による有害事象である．MRONJの誘因としては乳がんなど骨転移や，それに伴う疼痛緩和のために骨吸収抑制剤が投与されているケースが多い．本研究から，乳がんの骨転移メカニズムの一端が明らかになり，将来的に骨代謝回転を低下させることなく骨転移をコントロールできるようになれば，MRONJの発症を減らすことが可能となり，MRONJの解決に大きく貢献できる．
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