Novel Mechanism to Promote Bone Remodeling via Purinergic Signaling

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17152
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Shishido Kaori 東北大学, 歯学研究科, 大学院非常勤講師 (60894053)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ATP

Outline of Final Research Achievements

Adenosine triphosphate (ATP), an intracellular energy currency, is involved in bone remodeling, the coupling of bone resorption and bone formation, and this study examined its role in orthodontic treatment. ATP-degrading enzymes were found to be expressed in periodontal tissues, and the expression of ATP-degrading enzymes increased with tooth movement. This may lead to the discovery of a new target for ATP to activate orthodontic treatment-induced alveolar bone remodeling.

Free Research Field

歯科

Academic Significance and Societal Importance of the Research Achievements

本研究は、ATPが矯正歯科治療による歯槽骨リモデリングを活性化する新たなターゲットの発見に繋がると考えられる。また、国民病である歯周病においてもATPが骨吸収へ関与することが報告されているため、本研究成果は、歯周病と矯正歯科治療が組み合わさった複合的な病態における治療にも寄与する。