Human genome analysis of hemifacial microsomia from three-dimensional case classification.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17169
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Showa University
• Principal Investigator: NAGAHAMA RYO 昭和大学, 歯学部, 講師 (90783530)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Hemifacial microsomia

Outline of Final Research Achievements

The mandibular volume and length of the left and right mandibular canals of 23 Hemifacial microsomia patients were measured and subsequently statistically analyzed. The results showed a significant association between mandibular volume and mandibular canal length in Hemifacial microsomia type II patients, and the results were submitted for publication.
Although we were unable to analyze the results up to genetic analysis within the time frame of this study, we plan to continue this research project.

Free Research Field

orthodontics

Academic Significance and Societal Importance of the Research Achievements

今回の研究結果よりPruzansky Grade IIのHFM患者の患側において、下顎管長さと下顎骨体部体積には関連があることが明らかになった。また、Pruzansky Gradeが上昇するにつれて患側の下顎骨体部体積,下顎枝部体積,下顎管長さが減少する傾向があることが明らかとなった。HFMにおけるCBCTを用いた３次元的な下顎管長さと下顎骨体積の関係性を把握することは、HFM患者の成長発育に伴う顔貌の変形度合いを含む成長予測やその治療計画を立てる上での指標となる可能性が明らかとなった。