2022 Fiscal Year Final Research Report
The effect of oral bacteria-released extracellular vesicles on periodontal cells
| Project/Area Number |
21K17197
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57080:Social dentistry-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 細胞外分泌小胞 / 歯周病原菌 |
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| Outline of Final Research Achievements |
In this study, we analyzed the mechanism of how periodontal pathogens destroy periodontal tissue, focusing on extracellular vesicles. As a result, the extracellular vesicles released by periodontal pathogens contain powerful virulence factors specific to periodontal pathogens. Also, the extracellular vesicles can be transferred to various periodontal tissue cells via saliva and blood. The extracellular vesicles exhibited cytotoxic properties on periodontal cells including osteoblasts and fibroblasts. The type and activity of periodontal pathogens are considered to be closely related to the contents and cytotoxicity of the extracellular vesicles and are important indicators for measuring pathological changes and sanitary conditions of the oral cavity.
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| Free Research Field |
組織学
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| Academic Significance and Societal Importance of the Research Achievements |
歯周病原菌の『細胞外小胞』 は，主に微生物間の情報伝達や歯垢形成における役割について解析がなされてきた。そのため，様々な歯周組織の細胞の分化や機能に及ぼす影響についての幅広い研究は皆無に等しかった。本研究では，歯周病原菌の『細胞外小胞』 が菌本体に匹敵する病原性をもつことを明らかにし，宿主細胞に与える影響について解析した。この成果は，歯周病進行における歯周病原菌の『細胞外小胞』の役割を解明した点で学術的意義や社会的意義が高い。
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