2021 Fiscal Year Research-status Report
Interaction of genetic risk and early body mass index changes on neurodevelopmental disorders among Japanese children
| Project/Area Number |
21K17268
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Rahman Md.Shafiur 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60874360)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Neurodevelopment / ADHD / ASD / body mass index / genetic risk / autism |
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| Outline of Annual Research Achievements |
The objective of this study is to evaluate the interaction effect of genetic risk for neurodevelopmental disorders (NDDs) and body mass index (BMI) changes during infancy (birth to 24 months) on the severity of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) traits among Japanese children at age 6, 8, and 12 years while adjusting for other nosocomial/environmental factors. Our study included 1,258 children from Hamamatsu Birth Cohort for Mother and Child (HBC Study) with available follow-up information. The main exposures of this study are (1) changes in BMI (standard deviation scores) between birth to 24 months of age (2) genetic risk for NDDs. The outcomes are: symptoms of ADHD and ASD measured at 6, 8 and 12 years.
Data management for follow-up interviews conducted at 6 years and 8 years of age were completed. Polygenic risk scores for ADHD and ASD were estimated. We have completed follow-up interviews of 160 children aged 12 years and mother. We will continue to conduct follow-up interviews in the next academic year. Along with many background factors, the symptoms of ADHD and ASD among children at age 12 years are being measured using the Conners Rating Scale for ADHD, and Social Responsiveness Scale, the second version (SRS-2) respectively through a face-to-face interview.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
We conducted a literature review of existing studies on the topic of early BMI changes on neurodevelopment and related disorders. We did not find any similar studies, particularly among Japanese population.
Data management for existing data was completed. Polygenic risk score for autism spectrum disorder and attention deficit hyperactivity disorders were calculated. In addition, we have completed follow-up interviews of 160 children aged 12 years and their caregiver using a paper-and-pencil survey.
As part of this project, we published a paper on low birth weight, genetic risk and attention deficit hyperactivity disorder in BMC Medicine.
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| Strategy for Future Research Activity |
We are planning to complete the follow-up interviews for around 500 children aged 12 years by this academic year. In addition, we will complete initial data analysis for another manuscript.
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| Causes of Carryover |
Covid -19に関連する様々な制限やその影響のため、当初予想していた数の面接を行う事ができませんでした。そのため来年度は面接数を増やす予定であり、そのために研究助手を増員する必要があると考えており、この未使用額を来年度に含める予定です。
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