2022 Fiscal Year Research-status Report
Interaction of genetic risk and early body mass index changes on neurodevelopmental disorders among Japanese children
| Project/Area Number |
21K17268
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Rahman Md.Shafiur 浜松医科大学, 子どものこころの発達研究センター, 特任講師 (60874360)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Neurodevelopment / ADHD / ASD / body mass index / genetic risk / autism |
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| Outline of Annual Research Achievements |
This study aimed to investigate whether the interaction between genetic risk for neurodevelopmental disorders (NDDs) and changes in body mass index (BMI) during infancy (birth to 24 months) affects the severity of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) traits in Japanese children. The study population comprises 1,258 children from the Hamamatsu Birth Cohort for Mother and Child with available follow-up information. The main exposures of interest are (1) changes in BMI between birth and 24 months, and (2) genetic risk for NDDs. The outcomes are: symptoms of ADHD and ASD measured at 6, 8 and 12 years. Data analysis was completed for outcomes assessed at 6 years of age. Also, we conducted follow-up interviews among 422 children aged 12 years.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
Our systematic review on early BMI changes and neurodevelopmental disorders, conducted in the first year, found no similar studies among Japanese population. We also calculated the polygenic risk scores for autism spectrum disorder and attention deficit hyperactivity disorders by the first academic year.
Data management for follow-up interviews conducted when the children were 6 and 8 years old has been completed. Additionally, the initial analysis of the follow-up data collected when the children were 6 years old has been completed. Moreover, we already conducted follow-up interviews with 422 children who have now turned 12 years old, and assessed their ADHD and ASD symptoms using the Conners Rating Scale for ADHD and the Social Responsiveness Scale, respectively.
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| Strategy for Future Research Activity |
Our research project is still ongoing, and by the end of this academic year, we plan to conduct follow-up interviews with an additional 300 children who are now 12 years old. Furthermore, we intend to prepare two manuscripts based on our findings and submit them to international journals.
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| Causes of Carryover |
Covid -19に関連する様々な制限やその影響のため、当初予想していた数の面接を行う事ができませんでした。そのため来年度は面接数を増やす予定であり、そのために研究助手を増員する必要があると考えており、この未使用額を来年度に含める予定です。
加えて私は今年度２つの論文出版を考えており、その出版費用を支払う予定、さらに国際学会にて研究成果を発表をする予定であり、最終年度の今年はお金を必要と考えたため。
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[Journal Article] Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes2023
Author(s)
Sugiyama Mika, Tsuchiya Kenji J., Okubo Yusuke, Rahman Mohammad Shafiur, Uchiyama Satoshi, Harada Taeko, Iwabuchi Toshiki, Okumura Akemi, Nakayasu Chikako, Amma Yuko, Suzuki Haruka, Takahashi Nagahide, Kinsella-Kammerer Barbara, Nomura Yoko, Itoh Hiroaki, Nishimura Tomoko
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Journal Title
JAMA Pediatrics
Volume: 177(3)
Pages: 303～303
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits2023
Author(s)
Nishimura Tomoko, Takahashi Nagahide, Okumura Akemi, Harada Taeko, Iwabuchi Toshiki, Nakayasu Chikako, Rahman Mohammad Shafiur, Uchiyama Satoshi, Wakuta Manabu, Nomura Yoko, Takei Nori, Senju Atsushi, Tsuchiya Kenji J.
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 77
Pages: 282～289
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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