The true significance of platelet activation in hypothermia - physiological functional analysis and biological effects.

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K17328
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58040:Forensics medicine-related
• Research Institution: International University of Health and Welfare
• Principal Investigator: HORIOKA KIE 国際医療福祉大学, 医学部, 助教 (20897730)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 低体温症 / 血小板 / 脾臓 / PDMV

Outline of Final Research Achievements

This study aimed to clarify the function of activated platelets in hypothermia by analysing platelet-derived microvesicles (PDMVs) released by activated platelets during hypothermia and the molecules encapsulated in them, with the following results. (1) A comprehensive genetic analysis of platelets in the spleen and peripheral blood revealed that platelets activated by hypothermia release factors involved in tissue repair. (2) PDMV was demonstrated to be released from platelets in the spleen during hypothermia. (3) PDMV released from hypothermic intrasplenic platelets contained tissue repair factors.

Free Research Field

法医学

Academic Significance and Societal Importance of the Research Achievements

本研究成果から、低体温時の脾臓内血小板活性化がPDMVsを放出すること、さらにPDMVsに組織修復因子を内包するという新たな知見を得ることができた。今後、低体温症時に生じる生体へのダメージや活性化血小板やPDMVsの作用対象臓器を解析することによって、活性化血小板やPDMVsが生体に与える組織修復作用機序を解明できる可能性がある。これらの成果は、救急医学における低体温症治療の一助になることが期待される。