Clarification of the relationship between marginal biotin deficiency and fetal malformation by changing energy metabolism on the pregnancy period and its prevention

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17688
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kobe University
• Principal Investigator: Yuasa Masahiro 神戸大学, 人間発達環境学研究科, 助教 (00756174)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 潜在性ビオチン欠乏症 / 妊娠期 / エネルギー代謝 / 母体栄養 / 胎仔奇形

Outline of Final Research Achievements

In this study, we investigated the developing mechanism and timing of marginal biotin deficiency during the pregnancy period. In addition, the relationship between biotin deficiency and fetal malformation was studied. Pregnancy was a factor that decreased plasma biotin concentration. Additionally, pregnancy increased gluconeogenesis and amino acids catabolism which is related to biotin, by the metabolomics. On the other hand, biotin administration for biotin-deficient pregnant mice prevented the fetal cleft palate. Therefore, marginal biotin deficiency may be induced because pregnancy changes an energy metabolism, and biotin administration during the pregnancy period is important for preventing fetal malformation.

Free Research Field

栄養生化学

Academic Significance and Societal Importance of the Research Achievements

本研究により，妊娠期の潜在性ビオチン欠乏症の存在が確認され，ビオチン補給試験などの結果から，妊娠期のビオチン補給の必要性が示唆された．