2023 Fiscal Year Annual Research Report
Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cells
| Project/Area Number |
21K18062
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
ディリサラ アンジャネユル 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (70794353)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Liver sinusoidal coating |
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| Outline of Annual Research Achievements |
Our transient liver sinusoidal stealth coating strategy successfully increased the protein expression efficiency in the liver from mRNA-adsorbed liposomes than the level observed without two-arm-PEG-OligoLys preinjection. Intriguingly, the same sinusoidal stealth coating strategy decreased the liver expression of mRNA-loaded lipid nanoparticles and relocated them from liver to spleen. This discrepancy in the gene expression efficiency may be attributed to size and charge of nanoparticles.
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