Development of hybride catalysts using Coulomb interaction for asymmetric reactions

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K18855
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 27:Chemical engineering and related fields
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Yamazoe Seiji 東京都立大学, 理学研究科, 教授 (40510243)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: キラル反応 / 金属酸化物クラスター / 塩基触媒反応 / クーロン相互作用 / 反応場制御

Outline of Final Research Achievements

Organic cation salts of niobium oxide clusters were synthesized by exchanging the counter cation of tetrabutylammonium cation, with a chiral cation to control the reaction field of niobium oxide clusters with a strong basicity. After trying various methods, the desired chiral cation-niobium oxide cluster catalyst was successfully synthesized by the cation exchange method. The chirality of the salts and the structure of niobium oxide clusters were confirmed to be maintained by circular dichroism spectra, infrared absorption spectroscopy, and X-ray absorption spectroscopy. The synthesized catalysts were used in the reaction, and it was confirmed that the base catalytic reaction proceeded by the synthesized catalysts.

Free Research Field

触媒化学

Academic Significance and Societal Importance of the Research Achievements

塩基触媒を用いた難反応性のC－H結合の活性化による新たなエナンチオ選択的な炭素－炭素結合形成反応は，創薬，化成品合成の観点から将来なくてはならない化学技術の１つである．本研究では有機超強塩基に変わる新しい触媒として，キラルカチオン分子と強塩基触媒である金属酸化物クラスターアニオンからなる新しい不斉超強塩基金属酸化物触媒の開発に挑戦する．クラスター化学，触媒化学の異なる分野の知識を融合し，金属酸化物クラスターアニオンとキラルカチオン分子のクーロン相互作用を利用した超強塩基触媒よる不斉反応空間の構築を目指す本手法は，複雑な合成を必要としない新しい触媒合成法となると考えている．