Study on drug dynamics in comparison with RI probes and fluorescent probes

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K18919
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 31:Nuclear engineering, earth resources engineering, energy engineering, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAHASHI HIROYUKI 東京大学, 大学院工学系研究科(工学部), 教授 (70216753)
• Co-Investigator(Kenkyū-buntansha): 柳衛 宏宣 東京大学, 大学院工学系研究科(工学部), 客員研究員 (30212278)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: PET / FDG / RI / 蛍光体 / イメージング

Outline of Final Research Achievements

Fluorescent-labeled probes, which are produced by binding fluorescent substances to drugs, are widely used because they are easy to handle, but fluorescent molecules are usually large in size and have polarity as well. Therefore, it may change the dynamics inside the living body. In particular, if the behavior of drugs or molecules of interest is significantly different when taken up by cells in vivo, it is thought that their use will be limited. In this study, we systematically and quantitatively investigated the behavior of 18F-FDG, a glucose derivative probe that can be visualized by PET, and other fluorescently labeled probes in different tumor cells. It became clear that there was a quantitatively large difference in intracellular uptake.

Free Research Field

放射線計測

Academic Significance and Societal Importance of the Research Achievements

本研究は、現在、生物学・医学・薬学において広く用いられている、蛍光イメージングの根底にある信頼性、すなわち、忠実度がどれだけあり、どこまで得られた結果が信用できるものなのかについて再度問いかけなおす、という試みを行うものであるとともに、RIイメージングの可能性を再度提示するものである。