2021 Fiscal Year Research-status Report
| Project/Area Number |
21K18942
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
孫 洪涛 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 主幹研究員 (30571822)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 智彦 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 (50419264)
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| Project Period (FY) |
2021-07-09 – 2023-03-31
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| Keywords | 長残光蛍光ナノ粒子 / ナノ粒子 / 深紫外長残光 |
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| Outline of Annual Research Achievements |
The purpose of this study is to utilize nanoparticles exhibiting UVC long afterglow by X-ray excitation for the treatment of malignant tumors. In 2021, synthesis of nanoparticles showing UVC long afterglow was conducted. Pr3+-doped Cs2NaYF6 double perovskite nanoparticles were synthesized by a soft chemistry route. The detailed synthetic parameters that can affect the size distribution and photophysical properties of nanoparticles were thoroughly investigated. In particular, the parameters governing the optical properties were examined and determined. The structure and morphology of these particles were investigated. The obtained particles show UVC afterglow after charging by X-rays, and the afterglow properties of nanoparticles and micrometer-size particles were compared.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The attainment of nanoparticles with UVC afterglow is critical for this project. The efforts in 2021 make us obtain the particles showing UVC afterglow, which paves the way for the following biological application.
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| Strategy for Future Research Activity |
On one hand, the best surface modification method for nanoparticles for its biomedical application and model experiment of “UVC-emission-enhanced radiotherapy” in in vitro environment will be carried out. On the other hand, the novel method for the use of the UVC-afterglow particles for biomedical application will be explored.
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| Causes of Carryover |
The incurring amount (42円) is not enough to buy chemicals, which will be used for buying chemical in the next fiscal year.
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