Synthesis and medical application of deep ultraviolet persistent nanophosphors

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K18942
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
• Research Institution: National Institute for Materials Science
• Principal Investigator: SUN Hong-tao 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 主幹研究員 (30571822)
• Co-Investigator(Kenkyū-buntansha): 山崎 智彦 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 (50419264)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: ナノ粒子 / 深紫外残光

Outline of Final Research Achievements

The synthesis of Pr3+-doped Cs2NaYF6 double perovskite nanoparticles showing deep ultraviolet afterglow has been investigated. The hot-injection approach was adopted for the synthesis, and the detailed synthetic parameters affecting the size distribution and photophysical properties of nanoparticles were thoroughly investigated. In particular, the parameters governing the optical properties were examined and determined. Additionally, the structure and morphology of these nanoparticles were investigated. The obtained particles showed deep ultraviolet afterglow after charging by X-rays. It has been found that the surface ligand of nanoparticles can greatly affect the deep ultraviolet afterglow because of strong absorption of ligands in this spectral range. Removing the surface ligands greatly boost the intensity of deep ultraviolet afterglow, which benefits the medical application.

Free Research Field

物理化学、機能物性化学およびその関連分野

Academic Significance and Societal Importance of the Research Achievements

可視-近赤外波長域では、既に超残光蛍光体が報告されているが、深紫外波長域において超残光特性を示すナノ蛍光体は、現時点で世に存在しない。本研究成果は、深紫外超残光ナノ蛍光体がソフトケミストリーアプローチによって合成できることを実証した点で学術的意義が高く、医療応用への道が拓かれたと考える。今後研究を深化させ開発する「深紫外光放射ナノ粒子を活用した深紫外エミッション増強放射線療法」は、現行の放射線療法に革命を起こす可能性を秘めている点で社会的意義が高い。