Development of aggregation-type multifunctional catalysts and asymmetric control of photoreactions

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K18965
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 33:Organic chemistry and related fields
• Research Institution: University of Shizuoka
• Principal Investigator: Hamashima Yoshitaka 静岡県立大学, 薬学部, 教授 (40333900)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: 光エネルギー / 精密有機合成 / 分子会合 / 光反応 / 選択制制御 / イオン対 / 水素結合

Outline of Final Research Achievements

Molecular catalysts for precise control of synthetic reactions usually necessitate complex structures, and a set of the design, synthesis, and evaluation processes in catalyst development require an enormous amount of time and effort. In this study, we investigated asymmetric control of photoreaction by ion-pair-associated catalysts consisting of a chiral amine with an anion acceptor and a photosensitizing ketone with a strong acid. The combination of each of the two functional modules enabled us to construct a library of structurally defined ion-pair self-assembled catalysts. Furthermore, the catalytic function of the thus formed ion-pair catalysts was investigated, and it was found that the stereoselectivity of photocycloaddition between two intramolecular alkenes can be controlled.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

生体内ではタンパク質の会合により機能の多様性を実現している。構造モジュールを会合させて触媒機能を高度化することができれば、原料や目的の反応に応じたテーラーメイド触媒の開発に有効である。本研究で実証された概念は省エネ合成に貢献し得る光反応に利用され、反応の選択性を制御できることが示された。萌芽的な成果であるが、医薬品などの有用分子の合成を効率化する技術としての発展が期待できる。