2023 Fiscal Year Final Research Report
Tailor-made synthetic therapy by in vivo patrolling molecules
| Project/Area Number |
21K19042
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 37:Biomolecular chemistry and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2021-07-09 – 2024-03-31
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| Keywords | パターン認識 / 糖鎖クラスター / パトロール分子 / 生体内合成化学治療 / がん |
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| Outline of Final Research Achievements |
N-type glycans are the biomolecules that have important role for interaction between cells and proteins. Previously, we have found glycoalbumin molecules modified with N-glycans on albumin recognize various types of cancer cells depending on their glycan modification patterns (glycan pattern recognition). Here, we developed an innovative glycoalbumin capable of undergoing transformation and remodeling of its glycan pattern in vivo by in vivo chemical reaction, which induced its translocation from the initial target to a second one.
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| Free Research Field |
ケミカルバイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
「体内で常に疾患をパトロール・監視し、疾患を見つけると即時にその現場で治療を行う」。これはライフサイエンス分野における夢であるが、本研究ではこれを実現する初めてのプロトタイプ分子と体内有機合成化学を実現した。将来、体内を自由に動き回ることのできる分子が開発され、体内の複数の疾患のそれぞれの現場で望む治療分子を合成して効率的に治療することも可能であると期待される。
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