Enhanced production of natural compounds using the potential chemical signal response mechanisms of micro-organisms

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K19099
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 38:Agricultural chemistry and related fields
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Takahashi Shunji 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: ケミカルシグナル / 微生物二次代謝産物 / 天然化合物 / 生産誘導 / βーカルボリン / 放線菌 / 転写制御因子 / リベロマイシン

Outline of Final Research Achievements

Natural products are widely utilized because of their diverse structures and strong biological activities, and the development of methods to convert the genetic resources hidden in microorganisms into useful compound sources is an important issue in the post-genome era. It is desired to create natural products that can be used as seeds for pharmaceuticals and agrochemicals by activating biosynthetic gene clusters of secondary metabolites that exist in the actinomycete genome. In this study, we have utilized "chemical communication signals" to induce the production of microbial secondary metabolites without genetic modification.

Free Research Field

天然物生合成

Academic Significance and Societal Importance of the Research Achievements

生物間相互作用に仕組まれているケミカルコミュニケーションシグナルを解明することは、共生の学術的理解に繋がる。二次代謝物生産の潜在能力の開拓、未知遺伝子資源の化合物資源への変換が進展することによって、生命科学・医薬・農業分野への波及が期待される。