Visualization analysis for dynamics of chiral amino acids

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K19479
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 53:Organ-based internal medicine and related fields
• Research Institution: Kanazawa University
• Principal Investigator: Wada Takashi 金沢大学, その他部局等, その他 (40334784)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: キラルアミノ酸 / 腎臓病 / 高速原子間力顕微鏡

Outline of Final Research Achievements

This study was aimed to examine the detailed mechanisms of D-amino acids involved in the progression of kidney diseases. We have established the involvement of D-alanine and D-serine in murine models of acute kidney injury and chronic kidney disease. In addition, D-alanine and D-serine are both associated with human kidney diseases. However, detailed molecular mechanisms of D-amino acids remain investigated. In this study, using HS-AFM, we have examined the biological significance of D-amino acids, which would provide future insights for elucidation of molecular mechanisms of kidney diseases.

Free Research Field

腎臓学、内科学、臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

高速原子間力顕微鏡（HS-AFM）を用いることで、これまで困難であった腎障害の病態に果たす意義を解明することにつながる可能性がある。これまでの検討結果を生かして、生理的、腎臓病病態下でのキラルアミノ酸代謝の機序を明らかすることは学術的意義が高い。かかる検討成果により病態解明、予後改善にむけた取り組みをさらに展開する。今後は社会的にも重要な新しい学術体系の創発や、腎臓病の疾患バイオマーカー・治療シーズ開発につなげたい。