Development of new preventive or therapeutic strategies for hematopoietic neoplasms based on metabolic analysis.

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K19502
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
• Research Institution: Kanazawa University
• Principal Investigator: Hirao Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
• Co-Investigator(Kenkyū-buntansha): 加藤 将夫 金沢大学, 薬学系, 教授 (30251440)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: 代謝

Outline of Final Research Achievements

In this study, we aimed to establish a metabolite discovery system that contributes to the treatment and prevention of hematopoietic tumors by (1) conducting a comprehensive search for metabolites by metabolomics and (2) analyzing the functions of metabolites in disease models. As a result of our analysis, we observed that myeloproliferative disease was accelerated by a long-term high-fat diet. Metabolomic analysis revealed that many metabolites are altered by a high-fat diet, and that a metabolite had functions that inhibited the pathophysiology of the disease. Further development based on the findings of this study may lead to the identification of disease biomarkers and the development of therapeutic agents in the future.

Free Research Field

腫瘍学

Academic Significance and Societal Importance of the Research Achievements

昨今、様々な病態解明を目指して、ゲノミクス、プロテオミクス、エピジェネティクス解析など生体サンプルの網羅的解析が進んでいる。今回、我々は最新の質量分析法によるデータ収集、インフォマティクス解析を実施し、重要な代謝物を同定するシステムを構築することができた。本研究は，代謝物という観点から造血器疾患の病態の解明に挑む新しいアプローチとして、多くの疾患研究の次世代型プロトタイプになり得る。