2022 Fiscal Year Final Research Report
Elucidation of circulating cluster niche for hematogenous metastasis
Project/Area Number |
21K19535
|
Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
中島 雄太 熊本大学, 大学院先端科学研究部(工), 准教授 (70574341)
北村 裕介 熊本大学, 大学院先端科学研究部(工), 助教 (80433019)
|
Project Period (FY) |
2021-07-09 – 2023-03-31
|
Keywords | 血行性がん転移 / CTCs / 血小板 / 線維芽細胞 |
Outline of Final Research Achievements |
The purpose of this study was to clarify the significance of circulating tumor cells (CTCs) forming clusters with non-cancer cells such as platelets, macrophages, and fibroblasts. Clusters of cancer and non-cancer cells were detected in the blood of gastric cancer patients with distant metastasis and in a mouse model of hematogenous cancer metastasis. We demonstrated that disruption of the clusters with anti-platelet antibodies significantly suppressed hematogenous metastasis. Moreover, using in vivo imaging techniques, we captured CTC clusters circulating in blood vessels and showed their presence.
|
Free Research Field |
腫瘍生物学
|
Academic Significance and Societal Importance of the Research Achievements |
血行性がん転移に関する研究は長年にわたり行われてきたが、未だ転移を制御するまでに至っていない。本研究によって循環腫瘍細胞(CTCs)クラスターの形成が血行性転移形成に重要な意義を有していることが明らかになり、血行性転移や再発のバイオマーカーとしての循環腫瘍細胞(CTCs)検出に留まらず、がん細胞の生存をサポートするCTCクラスターを制御することで再発・転移を抑制する革新的な治療法開発に繋がることが期待できる。
|