2023 Fiscal Year Final Research Report

Molecular pathogenesis of central serous chorioretinopathy caused by VIPR2

Research Project

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Project/Area Number	21K19545
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	Hokkaido University
Principal Investigator	Ishida Susumu 北海道大学, 医学研究院, 教授 (10245558)
Co-Investigator(Kenkyū-buntansha)	齋藤理幸北海道大学, 大学病院, 助教 (90443944) 田川義晃北海道大学, 大学病院, 特任助教 (50632494)
Project Period (FY)	2021-07-09 – 2024-03-31
Keywords	VIPR2 / CSC
Outline of Final Research Achievements	In order to construct an animal model for central serous chorioretinopathy (CSC), we focused on the function of vasoactive intestinal peptide receptor (VIPR) 2 and established a knockout mouse model. Comparison of the retina and choroid of wild-type mice and VIPR2 knockout mice revealed no obvious differences in morphological analysis using fundus observation and optical coherence tomography, but functional analysis using electroretinography revealed a significantly enhanced response in VIPR2 knockout mice. The results suggest that the VIPR-2 molecule has some functional involvement in the retina or choroid.
Free Research Field	網膜
Academic Significance and Societal Importance of the Research Achievements	vasoactive intestinal peptide receptor (VIPR)2ノックアウトマウスでは野生型と比較して、網膜電図（ＥＲＧ）を用いることで、網膜の機能的応答の増強がみられることを確認できた。VIPR-2という分子が網膜あるいは脈絡膜について何らかの機能的関与があることを示唆する結果が得られたと考えている。当初の目的であるCSCモデル動物の確立には至っていないが、VIPR2の網脈絡膜機能への関与について今後の新規発見につながる可能性があると考えている。