In vivo molecular imaging for neuroinflammation.

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K19572
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Abe Koji 国立研究開発法人国立精神・神経医療研究センター, 病院, 院長 (20212540)
• Co-Investigator(Kenkyū-buntansha): 山下 徹 岡山大学, 医歯薬学域, 准教授 (60644408)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: IDOLマウス / in vivo imaging / 慢性脳低潅流 / 脳虚血

Outline of Final Research Achievements

We created a cerebral infarction model in IDOL mice and evaluated inflammation in the brain during the acute phase of cerebral infarction. Luciferase signaling itself has been detected, and analysis is currently underway to increase the number of animals. We plan to perform immunohistological analysis of the mice（n=5） at each time point, as well as immunohistological evaluation of various oxidative stress markers and Nissl staining.

Free Research Field

脳卒中、神経疾患全般

Academic Significance and Societal Importance of the Research Achievements

新規に開発されたIDOLマウスに応用することで、新たに血管性障害を伴った認知症における脳内炎症の空間的な分布や程度をin vivoで画像化（可視化）する新たなイメージング手法を挑戦しようとする点で大変意義深い。また超高齢化社会を迎えた日本において今後大きな問題となってくる血管性障害を伴った認知症の病態の理解および有効性の高い治療法を開発する上でも極めて意義深く普遍性が高いと考える。