2023 Fiscal Year Final Research Report
Analysis of taste function in oral-brain-gut axis using new photogenetical tool
| Project/Area Number |
21K19601
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 57:Oral science and related fields
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古株 彰一郎 九州歯科大学, 歯学部, 教授 (30448899)
高尾 知佳 岡山大学, 医歯薬学域, 講師 (40612429)
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| Project Period (FY) |
2021-07-09 – 2024-03-31
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| Keywords | 甘味 / 糖受容 / 遺伝子改変マウス / 光感受性Cre / 時空間的遺伝子発現調節 / 頭相インスリン分泌 |
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| Outline of Final Research Achievements |
In this study, we investigated sensory mechanisms contributing to the very early phase of insulin secretion induced by sugar intake (cephalic phase insulin secretion). To induce cephalic phase insulin secretion, it is necessary to activate the glucose-sensing mechanism via glucose transporters rather than the sugar-sensing pathway through the sweet taste receptors Tas1r2/Tas1r3. Additionally, using a new technique of genetic modification by light, we successfully induced gene expression in taste cells on the tongue through light stimulation.
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| Free Research Field |
口腔生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、口腔内のグルコーストランスポーターが口腔内での糖の受容に寄与することを示すとともに、そのシグナルが膵臓からのインスリン分泌を促す可能性について明らかとした。また光誘導性Creを用いることで、時空間的に味細胞の遺伝子発現をコントロールできる可能性を示した。
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