2023 Fiscal Year Final Research Report
Understanding of disrupted oral mirobiota colonized by non-oral taxa and its association with host's health conditions
| Project/Area Number |
21K19606
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 57:Oral science and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森 康雄 九州大学, 大学病院, 助教 (90573345)
奥 菜央理 九州大学, 歯学研究院, 助教 (60898972)
古田 美智子 九州大学, 歯学研究院, 准教授 (20509591)
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| Project Period (FY) |
2021-07-09 – 2024-03-31
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| Keywords | 口腔常在微生物叢 / 16S rRNA / 舌苔 / 異常定着 |
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| Outline of Final Research Achievements |
This study revealed details of compositional shift in oral indigenous microbiota of allogeneic hematopoietic stem cell transplantation patients. We also identified non-oral bacterial taxa colonizing disrupted oral microbiota in frail elderly adults and an association between their colonization and the hosts’health status. These results suggest that oral cavity could be a reservoir of unexpected bacterial taxa in compromised patients and frail elderly adults.
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| Free Research Field |
口腔衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は全身状態の悪化した者において口腔が病原微生物のリザーバーとなっている事例を示すともに、感染防御における正常口腔常在微生物叢の重要性を示すものである。今後口腔常在微生物叢を正常に保つ手法を確立できれば口腔微生物叢のモニタリングと積極的介入に基づく新しい感染防御システムの構築に繋がっていく可能性が期待できる。
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