Toxicity and immunological effect of metal and naturally derived biomaterial complex

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K19682
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Kawasaki Medical School
• Principal Investigator: Nishimura Yasumitsu 川崎医科大学, 医学部, 准教授 (90360271)
• Co-Investigator(Kenkyū-buntansha): 吉岡 大輔 川崎医科大学, 医学部, 助教 (40638318) ; 李 順姫 川崎医科大学, 医学部, 助教 (70414026)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: 毒性学 / 免疫機能 / 細胞死

Outline of Final Research Achievements

The material X that attracts attention is expected to be used as a complex of metal and naturally derived biomaterial, but on the other hand, its toxicity was unknown. Our preliminary trials revealed the interesting cytotoxicity of X. Therefore, with the aim of elucidating the toxic effect of X, we also considered the possibility as an antitumor and immunoactivation drug. Through cell culture experiments using human cell lines, various indicators were measured and analyzed by flow cytometry, RT-qPCR, and ELISA on the cytotoxic effects and immune function effects of X. As a result, the effective toxic effects of X on tumor cells associated with immune activation were revealed. X may become a new antitumor immunostimulant.

Free Research Field

毒性学

Academic Significance and Societal Importance of the Research Achievements

本研究課題より得られた研究成果により、Xが新たな抗腫瘍免疫賦活剤となる可能性が明らかとなった。Xは上市されている薬剤には当てはまらず、新たな創薬モダリティを拓く可能性が高い。従って、研究成果の学術的意義や社会的意義は大きく、また今後の更なる発展が期待できる。