2022 Fiscal Year Final Research Report
Elucidation of plasticity of white matter tracts for establishing a new rehabilitation strategy based on recovery expectancy
| Project/Area Number |
21K19705
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中田 光俊 金沢大学, 医学系, 教授 (20334774)
木下 雅史 金沢大学, 医学系, 講師 (50525045)
篠原 治道 金沢大学, 医学系, 客員教授 (20135007)
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| Project Period (FY) |
2021-07-09 – 2023-03-31
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| Keywords | 可塑性 / 白質神経線維 / リハビリテーション |
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| Outline of Final Research Achievements |
The brain is known to have plasticity to adapt to its environment. For a long time, it was believed that plasticity occurred in the cerebral cortex and not in white matter tract. The purpose of this project is to clarify the presence or absence of plasticity and its limits in each white matter tract running in the brain. In this study, we first attempted to examine whether white matter tract can recover following damage. We found that within a single white matter bundle, there are areas that are inviolable and recoverable. Next, we attempted to answer the question at the core of this study: Do white matter fibers have plasticity? We found that white matter tracts are displaced as the lesion slowly progresses, and that new fibers may be observed after lesion excision. Furthermore, when new fibers are found, the lesion is not permanent.
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| Free Research Field |
リハビリテーション
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| Academic Significance and Societal Importance of the Research Achievements |
従来，白質神経線維は損傷すると回復しないと考えられてきた．本研究は，白質神経線維には損傷されても回復可能な領域があること，そして恒久的な障害の原因となる領域があることを明らかにした点で学術的意義が高い．本研究成果をリハビリテーションに応用することにより，治療方針の抜本的な改革が期待できる．
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