2023 Fiscal Year Final Research Report

Regenerative medicine and Rehabilitation after peripheral nerve injury

Research Project

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Project/Area Number	21K19709
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research Institution	Kyoto University
Principal Investigator	Kuroki Hiroshi 京都大学, 医学研究科, 教授 (20170110)
Co-Investigator(Kenkyū-buntansha)	谷間桃子 (長井) 京都大学, 医学研究科, 助教 (50755676) 伊藤明良京都大学, 医学研究科, 講師 (50762134)
Project Period (FY)	2021-07-09 – 2024-03-31
Keywords	リハビリテーション / 再生医療 / 末梢神経損傷 / 理学療法 / 超音波療法 / 非侵襲的磁気刺激
Outline of Final Research Achievements	In order to elucidate the mechanism of reinnervation after peripheral nerve injury by using ultrasound treatment and to verify the ability to suppress cell death of dorsal root ganglion (DRG) neurons by applying non-invasive magnetic stimulation, this project was conducted. The results obtained indicate that (1) ultrasound treatment up to 1 week after injury is important to promote reinnervation and to reduce proinflammatory macrophages; and (2) non-invasive magnetic stimulation up to 1 week after injury may suppress DRG neuron cell death.
Free Research Field	リハビリテーション医学　理学療法学
Academic Significance and Societal Importance of the Research Achievements	本課題の研究成果は、末梢神経損傷に対するリハビリテーションの臨床において、超音波治療による神経再生促進の可能性を示したこと、および非侵襲的磁気刺激を腰髄後根神経節部位に行うことで、後根神経節ニューロンの細胞死を抑制できる可能性を提示したことにあり、この領域の発展に貢献していると考える。