What is essentiality of cancer nanomedicine

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K19906
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Kyoto University
• Principal Investigator: Komatsu Naoki 京都大学, 人間・環境学研究科, 教授 (30253008)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: ナノ医療 / 癌 / ナノ粒子

Outline of Final Research Achievements

First, we prepared boron carbide nanoparticles with various structures and properties which are functionalized with polyglycerol. Second, we applied this materials intravenously to cancered mice from tail vein. After a few days later, we picked up the organs, tumor and blood, and determined the concentrations of boron-10 by prompt gamma ray analyses. As a result, we found that the boron-10 accumulation in tumor is found to be consistent with the suppression of the tumor growth.

Free Research Field

ナノ材料化学

Academic Significance and Societal Importance of the Research Achievements

腫瘍を標的とする薬物送達システム（drug delivery system）において、送達効率の向上は、非常に重要である。その中で、送達物資の構造や物性の影響がいかに大きいかについて明らかにした本研究の意義は、非常に大きい。また、長年、社会問題となっている癌の治療にも新たな考えを提供することとなり、その解決に大きく貢献することになると確信する。