2023 Fiscal Year Final Research Report
Challenge of the Dementia Treatment by Creating the Multi-Action Biomaterial with the Recovery of Nerve Cells and the Elimination of Pathogenic Substances
Project/Area Number |
21K19921
|
Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
|
Research Institution | Tokyo Metropolitan University |
Principal Investigator |
|
Project Period (FY) |
2021-07-09 – 2024-03-31
|
Keywords | 神経細胞回復 / 病因物質排除 / マルチ作用型バイオマテリアル / 認知症治療 |
Outline of Final Research Achievements |
We have designed a biomaterial (insulin modified with cholesterol-end modified poly(ethylene glycol), Chol-PEG) with multiple mechanisms of action for neuronal recovery (action of insulin) and elimination of pathogenic agents (action of Chol-PEG), and challenged the treatment of Alzheimer's disease. In this study, we found that Chol-PEG forms vesicles when the PEG molecular weight of Chol-PEG is shortened to approximately 500, and confirmed the multiple mechanisms of action: the encapsulation of insulin into the vesicles and the ability of Chol-PEG itself to inhibit amyloid β aggregation.
|
Free Research Field |
生体材料学
|
Academic Significance and Societal Importance of the Research Achievements |
Chol-PEG500は水系溶媒中で自発的に均一な粒子径100nm程度のベシクルを形成することを見出し、Chol-PEG500ベシクルへのインスリン等の薬物の内包が簡便であることから、デリバリーキャリアとしての有用性を確認した。さらに、デリバリーキャリアであるChol-PEG自身にも、Aβの凝集阻害という薬効が確認されたことから、Chol-PEG単独投与によるアルツハイマー病(AD)の予防のみならず、インスリンを含めた内包する様々な薬剤によるマルチな作用機序によるADの根治治療につながることが期待できる。
|