Establishing design principles for spray dried nanofibrillar supraparticles towards modular pulmonary drug delivery systems

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K20495
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0401:Materials engineering, chemical engineering, and related fields
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: KAMARAINEN Tero 大阪医科薬科大学, 薬学部, 特任研究員 (20909890)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: Supraparticles / Spray drying / Amyloid nanofibrils / Silver nanowires / Silica nanoparticles / Phytoglycogen / Crumpling

Outline of Final Research Achievements

Supraparticles are particle constructs composed of smaller particle building blocks. Our results show that protein nanofibrils can be used to create supraparticles with crumpled shapes when mixed with nanoparticles (diameter below 1/10000 of a millimeter) and assembled using the spray drying technique. Larger nanoparticles required more nanofibrils for the creation of crumpled supraparticles, whereas building block softness and aspect ratio decreased the propensity of the nanofibrils to modify the supraparticle shape. The nanofibrils remained effective in creating crumpled shapes when drugs were incorporated within the supraparticle structure.

Free Research Field

Materials science

Academic Significance and Societal Importance of the Research Achievements

超微粒子は、製薬業界や化学業界など、多くの有望な用途があります。我々の研究結果は、産業関連の粒子形成技術 (スプレー乾燥) を使用してタンパク質ナノフィブリルを超微粒子に組み込むことで、超微粒子の構造を変更する方法に関する知識を広げる。材料の性能は一般にその構造 (構造と特性の関係) と関連しているため、我々の研究結果は、様々な用途で超微粒子の性能を変更するためにすぐに採用できる可能性があります。我々の研究結果は、同様の有用性を持つ可能性のある他のナノフィブリル構成要素に関するさらなる研究の動機にもなりうる。