Study of effective utilization of transplanted organs using extracorporeal membrane oxygenation (ECMO)

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20510
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Asahikawa Medical College
• Principal Investigator: OHARA Mizuho 旭川医科大学, 医学部, 特任助教 (80596304)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 心停止ドナー / 膜型人工肺 / 臓器保存 / 虚血再灌流障害 / 肝移植

Outline of Final Research Achievements

The use of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. After cardiac arrest, Porcine livers were divided into three groups. In group 1, non-in situ ECMO and grafts were preserved by hypothermic oxygenated machine perfusion (HOPE). In group2, in situ ECMO and grafts were preserved by HOPE. In group 3, in situ ECMO and grafts were preserved by cold storage. The combined use of in situ ECMO and HOPE is essential for the functional recovery of DCD liver grafts.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、長時間の温阻血後に常温でECMOを使用することで、肝細胞障害が著明に改善された。臓器移植の現場においては、ドナーとレシピエントの病院間の輸送のために一定時間の低温保存を余儀なくされているが、ここで低温機械灌流を行うことで、ECMOの利点を高め、また灌流中に移植前評価が可能となる。ECMOと低温機械灌流を組み合わせた保存により、心停止ドナー臓器において、臓器機能を回復させ、虚血再灌流障害を抑制する可能性があり、ドナー不足解消への一つの解決策となり得る。