Biodegradable implantable flow sensor for on-site continuous monitoring of respiratory system

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20518
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Hiroshima City University
• Principal Investigator: Al Farisi Muhammad Salman 広島市立大学, 情報科学研究科, 助教 (50910486)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: MEMS / 流量センサ / 生分解性 / 埋込み型 / フレキシブル

Outline of Final Research Achievements

Respiratory diseases such as lung cancer and chronic obstructive pulmonary disease (COPD) have become major causes of death worldwide. Furthermore, the recent outbreak of novel coronavirus infection (COVID-19) has exacerbated the situation. Although there are currently no specific treatments for these infectious diseases, it is believed that early detection and continuous monitoring of high-risk patients can delay their progression. In this study, we developed a miniaturized thermal-based flow sensor using micro-electro mechanical systems (MEMS) technology. We then demonstrated its capability for respiratory measurement and monitoring through model experiments using an artificial ventilator and animal experiments using rat. Subsequently, we fabricated a biodegradable flow sensor employing a similar mechanism.

Free Research Field

ナノマイクロシステム

Academic Significance and Societal Importance of the Research Achievements

本研究ではMEMS流量センサを用いて呼吸の計測・モニタリングが可能であることを実証した。また、生分解性材料を用いたMEMS流量センサの作製技術も確立した。本センサを用いることで呼吸モニタリングが可能にし、センサが動作期間を超えた後に自然に消え、デバイスを回収するための手術が不要になる。