2022 Fiscal Year Annual Research Report
Porous Microneedles filled with an Glucose-responsive Hydrogel for Self-Regulated Insulin Delivery
| Project/Area Number |
21K20525
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| Research Institution | Kanagawa Institute of Industrial Sclence and Technology |
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Principal Investigator |
Barthelmes Kevin 地方独立行政法人神奈川県立産業技術総合研究所, 「貼るだけ人工膵臓」プロジェクト (松元P), 研究員(任期有) (60908078)
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Keywords | Microneedle / Drug release / Hydrogel / Encapsulation / Diabetes / Insulin |
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| Outline of Annual Research Achievements |
Our purpose was to fabricate mechanically-stable, porous microneedle (PMN) arrays strengthened by a drug-releasing hydrogel filling. We have investigated cellulose acetate (CA) as a polymeric material for the PMN fabrication. The arrays were made by diffusion of water into solution of CA in DMSO. The slow exchange of the solvents results in precipitation of the polymer and after optimization of the conditions, sharp and uniform microneedles could be formed. The needles featured very high porosity (~90%), narrow pore size (~2 μm) and moderate mechanical strength (~0.2 N). Since CA is more hydrophilic material it could easily absorb our pre-gel solution (mixture of monomer solutions). The hydrogel was formed in the interconnected pores after UV-polymerization of the monomer soaked PMN array.
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