2022 Fiscal Year Final Research Report
A new approach to search for the marine natural compounds from the mixtures of deep sea organisms
Project/Area Number |
21K20577
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0601:Agricultural chemistry and related fields
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Research Institution | Waseda University |
Principal Investigator |
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Project Period (FY) |
2021-08-30 – 2023-03-31
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Keywords | 天然物化学 / 天然化合物 / 深海生物 / ドレッジ採集 |
Outline of Final Research Achievements |
Bathophilous organisms have evaluated their metabolism and adapted to the extreme environment different from those of terrestrial. As the result, secondary metabolites from such organisms one of quite unique structures and bioactivities. Many of these organisms are collected by dredging and, as the results, become crushed and fragmented small pieces making it difficult to obtain enough amount of the classified samples. In this study, we focused on the unclassified small fragment mixtures of the deep sea organisms as the source of drug leads, and explored the various natural products from the extract of the mixture.
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Free Research Field |
天然物化学
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Academic Significance and Societal Importance of the Research Achievements |
これまで未利用資源とされてきた貴重な深海性生物の断片を有効利用することで深海性の海洋生物由来の天然化合物を明らかにできた。近年、天然から十分量の新規生物活性化合物を発見することが難しくなってきていることから、医薬品開発研究においても合成化合物の比重が増大しつつある。しかしながら、現在でも合成品を凌駕した多様な化学骨格を有する天然化合物は依然として重要な医薬品の探索ソースと考えられるため、医薬品候補となる新たな化合物探索を可能とした本研究の意義は大きい。
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