2022 Fiscal Year Final Research Report
Establishing Parkinson's disease registry focusing on advanced MRI as a surrogate marker
| Project/Area Number |
21K20698
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Keywords | パーキンソン病 / レジストリ / 先進的拡散MRI / 衝動制御障害 / セレギリン / 白質微小構造 |
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| Outline of Final Research Achievements |
Parkinson's disease (PD) registry, the main project, has been established to have annual evaluation including clinical scores taken by medical doctors, psychologists, and questionnaires, as well as blood samples and advanced MRI. At the end of 2022, it holds 812 registry, with 312 longitudinal cases, 508 blood samples, and 513 advanced MRI data.
Based on this database, the relationship between impulsive compulsive behaviors and cerebral white matter microstructure change was detected, and the result was published on Annals of Clinical and Translational Neurology (IF=5.43). Also, another study on the white matter microstructure difference between PD patients with and without selegiline treatment was conducted and presented at several congresses and submitted to a journal..
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| Free Research Field |
神経内科
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| Academic Significance and Societal Importance of the Research Achievements |
PDデータベースに基づき様々な研究を展開することが可能となった。
衝動制御障害を有するPD患者で特定の白質経路の微小構造変化が抑制されていることを見いだした。この白質微小構造が保たれている患者に、衝動制御障害のリスク因子であるドパミンアゴニストを使用することで衝動制御障害が誘発されやすいことも予想され、テーラーメイド医療につながる成果と考える。また特定の白質経路における病的な微小構造の変化がセレギリン内服患者では抑制されている可能性を示唆する結果も得た。セレギリンの効果を示す新たな所見であり、既存のPD治療を前進させる成果と言える。
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