2022 Fiscal Year Final Research Report
Development of gastric cancer in a dish by gene editing
Project/Area Number |
21K20726
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0801:Pharmaceutical sciences and related fields
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Research Institution | Wakayama Medical University |
Principal Investigator |
Hishida Tomoaki 和歌山県立医科大学, 薬学部, 准教授 (80521062)
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Project Period (FY) |
2021-08-30 – 2023-03-31
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Keywords | 発がん / 老化 / MYC |
Outline of Final Research Achievements |
We focused on Sox2-positive cells, which are adult stem cells. In this study, we found that (1) Sox2-expressing esophageal epithelial cells are resistant to senescence and that MYC supports this resistance, and (2) combination of forced expression of MYC with deletion of p53in Sox2-expressing gastric epithelial cells drives metastatic undifferentiated gastric carcinoma, and that Top2a is involved in the growth of this undifferentiated gastric carcinoma. We have submitted a paper on cellular senescence resistance of esophageal epithelial cells to Frontiers in Cell and Developmental Biology, and a paper on carcinogenesis of gastric epithelium is in preparation for submission.
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Free Research Field |
発がん、再生、老化
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Academic Significance and Societal Importance of the Research Achievements |
食道細胞が細胞老化に抵抗性があるという特殊性とその分子機序についてその一端を明らかにした。この成果は老化の分子機序の一端を明らかにすることに加え、組織に違いがあることを示唆するもので、高齢化社会における老化研究のニーズに合致するものだと考えられる。 また、胃がんについては転移性未分化胃がんを生体内で誘導的に作製するモデルであり、我が国で依然として発症率、致死率が高い胃がんを標的とした分子機序解明及び創薬に結びつく成果であると考えられる。
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