Effects of Muse cell on a mouse model with Acute encephalopathy

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K20774
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Tottori University
• Principal Investigator: Kawaguchi Tatsuya 鳥取大学, 医学部, プロジェクト研究員 (30881594)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: acute encephalopathy / Muse cell / cytokine-stome

Outline of Final Research Achievements

This study was designed to investigate the effects of multilineage-differentiating stress-enduring (Muse) cells on a mouse model of acute encephalopathy (AE). Muse cells, non-Muse cells, and phosphate-buffered saline (PBS) were administered to mice models of acute encephalopathy, and the efficacy was evaluated by quantifying survival rate, body weight change, and cytokines (IL-6, IL-10, TNFα) by RT-PCR. The results suggest that Muse cells are useful for improving survival and regulating cytokines in acute encephalopathy.Muse cells were suggested to be effective in improving survival and regulating cytokinesis in acute encephalopathy.

Free Research Field

急性脳症

Academic Significance and Societal Importance of the Research Achievements

急性脳症は主に小児において発症し、種々の感染症を契機に高熱に伴う痙攣重積、意識障害が生じ、高い死亡率を示す疾患である。 更に精神運動発達障害や難治性てんかんなどの重い後遺症を残すが、根治的な治療法は確立されておらず、医学的・社会的に大きな課題である。本研究ではMuse細胞が急性脳症の死亡率の改善や抗炎症サイトカインの増加に効果があることが示唆された。Muse細胞が急性脳症の新しい根治療法となれば、急性脳症による死亡率、重篤な後遺症を軽減できる可能性がある。