2022 Fiscal Year Final Research Report
Targeting p97/VCP in Multiple Myeloma
| Project/Area Number |
21K20840
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Keywords | 多発性骨髄腫 / p97/VCP / ERストレス |
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| Outline of Final Research Achievements |
Our new findings include autophagy inhibition and DNA-damage response induction with p97/VCP knock-down. Furthermore, we synthesized several novel chemical compounds by modifying OSSL_325096, and some of these compounds showed anti-proliferative activity against the KMS12PE myeloma cell line. Detailed mechanisms and molecular activities for these compounds are under investigation.
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| Free Research Field |
血液腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、p97/VCPの骨髄腫細胞内での新たな役割が明らかになるとともに、p97/VCPを標的とした新規薬剤開発への足掛かりとなった。
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