2022 Fiscal Year Final Research Report
Development of a Novel Treatment for Metabolic Syndrome Using Conditioned medium from stem cells derived from human exfoliated deciduous teeth (SHED-CM)
Project/Area Number |
21K20863
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0902:General internal medicine and related fields
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Research Institution | Nagoya University |
Principal Investigator |
Muto Hisanori 名古屋大学, 医学部附属病院, 医員 (80909127)
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Project Period (FY) |
2021-08-30 – 2023-03-31
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Keywords | NASH / NAFLD / 乳歯歯髄幹細胞 / ミトコンドリア |
Outline of Final Research Achievements |
Conditioned medium from stem cells derived from human exfoliated deciduous teeth (SHED-CM) contains many stem cell-derived factors, and its usefulness in various disease models has been reported. In this study, we found that SHED-CM activated HepG2 mitochondrial function in vitro and reduced steatosis in the liver of a NASH mouse model. These results suggest that SHED-CM may contribute to the amelioration of NASH by promoting lipolysis through enhancing β-oxidation.
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Free Research Field |
消化器内科
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Academic Significance and Societal Importance of the Research Achievements |
NASH/NAFLDは近年世界的に問題になるとともに、比較的肥満が少ないとされる本邦においても、今後もますますNAFLDの有病率が上昇していくことが予測されている。しかしながら現在のところ有効な薬物治療は限られている。今回の検討により、SHED-CMにこれまで報告されてきた抗炎症作用に加えて、ミトコンドリア機能の活性化を介する作用が確認された。SHED-CMは複雑な病態を有するNASHにおいて、その多面的な作用から有望な治療戦略になると考えられる。
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