Relationship between leaky gut, a potential inducer of NAFLD, and acid secretion inhibitors.

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20904
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Kyushu University
• Principal Investigator: Minoda Yosuke 九州大学, 大学病院, 助教 (60908664)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 腸管バリア機能 / 酸分泌抑制薬 / 腸内細菌叢

Outline of Final Research Achievements

When taking acid secretion inhibitory drugs, there was a decrease in impedance values in the ileum, and an enhancement of the permeability of the gastrointestinal mucosal barrier function. Moreover, while the intestinal bacterial flora changed with the administration of these drugs, there was little change observed in the fungal flora. During the study period, no significant onset of NAFLD or significant increase in visceral or subcutaneous fat was observed due to the administration of acid secretion inhibitors. These results might be affected by bias in the selection of the study population. Although further research is needed, it has been suggested that these changes in the intestinal bacterial flora could be contributing to a decrease in mucosal barrier function.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

本研究結果は胃酸分泌抑制薬がLeaky gutを引き起こす可能性を示している。酸分泌抑制薬は世界的にも広く普及している反面、その長期使用の影響はいまだにはっきりしない部分がある。特に近年極力な酸分泌抑制薬が登場しており、酸分泌抑制薬がLeaky gutを誘導するという成果は今後の研究においても重要な結果であり、本研究は社会的な意義が高いものと考えられる。