The role of the microbiome in intestinal adaptation in patients with pediatric short bowel syndrome

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20941
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0905:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Chiba University
• Principal Investigator: Kawaguchi Yunosuke 千葉大学, 大学院医学研究院, 特任研究員 (20896625)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 短腸症候群 / 腸管不全 / 腸内細菌叢 / 腸管順応

Outline of Final Research Achievements

A database of patients with short bowel syndrome at our hospital was constructed. This enabled us to obtain a more accurate clinical features of short bowel syndrome. Furthermore, we passed the ethical review and collected fecal samples from patients with short bowel syndrome. Although the number of patients is small, we have collected samples over time and are currently analyzing them. We are also analyzing the onset of D-type lactic acidosis associated with short bowel syndrome from the viewpoint of intestinal microbiota.
In addition, a review of previous reports was conducted, and a meta-analysis of the intestinal microbiota was performed based on the database of previous papers.
We were able to visualize and understand the results of SBS fecal analysis, which were different in each paper.

Free Research Field

小児外科

Academic Significance and Societal Importance of the Research Achievements

短腸症候群は、腸管の機能低下に伴い生命予後に重大な影響を与える病気であり、多くの患者には長期の入院や在宅中心静脈栄養などが必要となる疾患です。そのため、研究によって、腸管順応における腸内細菌の役割を明らかにすることで、短腸症候群患者の腸管順応能力を向上させる新たな治療法やケア方法が開発される可能性があります。これにより、患者の栄養状態や生活の質が改善され、日常生活への参加と自立が促進されることが期待されます。