2023 Fiscal Year Final Research Report
The effects of peripheral blood-derived and bone marrow-derived platelet-rich fibrin for osteochondral defects in rabbits
| Project/Area Number |
21K20960
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0906:Surgery related to the biological and sensory functions and related fields
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2021-08-30 – 2024-03-31
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| Keywords | 再生医療 / 骨軟骨再生 / 多血小板フィブリン / 骨髄 |
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| Outline of Final Research Achievements |
Micro-CT and histopathological analyses were performed to evaluate the effects of peripheral blood-derived platelet-rich fibrin (P-PRF) and bone marrow-derived platelet-rich fibrin (BM-PRF) on osteochondral defects in rabbits. Compared with transplanting P-RPF made from peripheral blood into the osteochondral defect or osteochondral defect only, transplantation of BM-PRF made from bone marrow accelerated the repair of subchondral bone and led to the osteochondral repair with hyaline-like cartilage tissue. Therefore, these findings suggest that BM-PRF may contribute to the treatment of osteochondral defects.
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| Free Research Field |
再生医療
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| Academic Significance and Societal Importance of the Research Achievements |
家兎膝骨軟骨欠損モデルに対する末梢血由来多血小板フィブリン（P-PRF）と骨髄由来多血小板フィブリン（BM-PRF）の骨軟骨修復効果について調査した初めての研究であり，BM-PRFは骨軟骨欠損治療に寄与できる可能性を明らかにした．
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