Dynamic analysis of anti-carcinogenic ions by harmonizing of Quantum / X-ray beam technology with mathematical modeling

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21009
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Naito Katsuaki 大阪大学, 歯学部附属病院, 医員 (70909506)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 根面う蝕 / PIXE/PIGE / X線吸収分光 / 有限要素法

Outline of Final Research Achievements

The aim of this study was to clarify temporally and spatially the ionic dynamics in dentin when anti-cariogenic ions such as fluoride, calsium, zinc, and strontium were incorporated into dentin. Using X-ray absorption spectroscopy, one of the quantum and X-ray beam techniques, it was suggested that the zinc ion was involved in improving the acid resistance enhancement and may have a covalent bond with four-fold coordination in dentin. In the finite element analysis, we were able to visualize the diffusion of fluoride ions in three dimensions using a mathematical model that incorporated fluid flow in dentin tubules to follow the Hagen-Poiseuille flow.

Free Research Field

う蝕学

Academic Significance and Societal Importance of the Research Achievements

本研究は，結合様式という原子レベルでの違いが，耐酸性というマクロな現象に影響を与えることを示した．また理論的にイオンの拡散現象を明らかにすることで，拡散に関与する因子を明確にできた．これらの結果は，う蝕研究において，①原子レベルでの解析が，これまで未知とされてきたう蝕の動態現象の解明につながること，②理論的なアプローチは，理論的な背景に基づいた革新的な材料開発に発展する可能性があること，これら2点で重要な意義をもつといえる．