Exploration of the structural isomer of myo-inositol which exhibit specific augmentation of mandibular endochondral growth

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K21026
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Tsurumi University
• Principal Investigator: tohyama syunnosuke 鶴見大学, 歯学部, 学部助手 (10908940)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: Myo-inositol / 下顎骨特異的成長

Outline of Final Research Achievements

In this study, to elucidate the effects of myo-inositol on cartilage differentiation, we conducted culture experiments using ATDC5 cells, which have cartilage differentiation potential and are derived from mice. The cells were divided into three groups: (1) control group, (2) positive control group (BMP4 group), and (3) experimental group (myo-inositol group). The expression of ColX, a terminal marker of cartilage differentiation, was compared among these groups. As a result, it was confirmed that cartilage differentiation of ATDC5 cells was significantly enhanced in the experimental group with the addition of myo-inositol. This suggests that myo-inositol not only promotes mandibular growth but is also beneficial for maintaining cartilage homeostasis.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、Myo-inositolが軟骨細胞の分化を促進する能力を持つことを明らかにし、特にATDC5細胞におけるSox9の増強を通じてその効果を示した。これにより、Myo-inositolが下顎の成長を促進し、軟骨の恒常性を維持するための作用があることが示唆された。Pik3CDを介した細胞内シグナル伝達の理解を深め、軟骨形成メカニズムの新たな知見になる。将来的な臨床応用にMyo-inositolのサプリメントとしての可能性が示され、下顎後退症に対し新しい治療を提供することが期待される。今後の研究で、さらに詳細な作用機序が明らかになれば、より効果的な治療法の開発につながる可能性がある。