The combined application of mineral trioxide aggregate containing phosphorylated pullulan and colloidal platinum nanoparticles to control inflammation and facilitate dental pulp regeneration

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21028
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Hokkaido University
• Principal Investigator: Islam Rafiqul 北海道大学, 歯学研究院, 助教 (00906414)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: Direct pulp capping / MTA / CPNs / Pullulan

Outline of Final Research Achievements

The study aimed to evaluate the potential of a combination of mineral trioxide aggregate and phosphorylated pullulan for direct pulp capping (DPC), a dental procedure that involves placing a material directly on an exposed pulp to promote healing and prevent infection. We compared the effectiveness of the novel MTAPPL material to that of conventional MTA in inducing mineralized tissue formation and inflammatory pulpal responses. The results showed that MTAPPL exhibits comparable outcomes to MTA, indicating its potential as a viable alternative for DPC.

Additionally, the study investigated the healing response of colloidal platinum nanoparticles (CPNs) in exposed dental pulp. We found that the presence of endothelial cells, which are involved in angiogenesis, were present in the dental pulp after treatment with CPNs, indicating a favorable healing response. Overall, the study suggests that the combination of MTAPPL and CPNs hold promise for use in dental pulp therapy.

Free Research Field

Dentistry

Academic Significance and Societal Importance of the Research Achievements

Using CPNs and MTAPPL has significant impact in the dental field. The study develops new materials and approaches for dental pulp therapy, overcoming limitations of traditional materials and leading to better patient outcomes and quality of life.