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2022 Fiscal Year Final Research Report

Effects of adipocyte-derived CCL19 on periodontitis

Research Project

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Project/Area Number 21K21043
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0907:Oral science and related fields
Research InstitutionKyushu University

Principal Investigator

Hayashi Masato  九州大学, 歯学研究院, 共同研究員 (70906338)

Project Period (FY) 2021-08-30 – 2023-03-31
Keywords脂肪細胞 / CCL19 / 歯周炎
Outline of Final Research Achievements

In the high-fat diet group, Ccl19 knock-in mice increased the distance between the cement-enamel junction and the alveolar bone crest and the exposed root area compared with wild-type mice.
RAW264.7 cells stimulated with recombinant CCL19 tended to increase gene expression of TNF-α and IL-1β.
These results suggest that high expression of CCL19 in adipocytes may contribute to the exacerbation of periodontitis in obese individuals. In addition, CCL19 may have a pro-inflammatory effect on macrophages.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、肥満状態において、脂肪細胞におけるCCL19の高発現が歯周炎の増悪に関与する可能性が示唆された。また、CCL19はマクロファージに対し炎症促進性に作用する可能性が示された。したがってCCL19が肥満および歯周病の病態を関連づける分子の一つであることが考えられる。
本研究の結果をもとに今後、詳細な機序を見出せれば、近年注目されている肥満における慢性炎症・糖脂質代謝と免疫制御機構との関連性の一端を明らかにしうる。

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Published: 2024-01-30  

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