2022 Fiscal Year Final Research Report
New cytotherapy for osseointegration in implants combined with dedifferentiated adipocytes and fibrin gels
| Project/Area Number |
21K21052
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Keywords | 脱分化脂肪細胞 / AFG / 骨再生 / オッセオインテグレーション |
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| Outline of Final Research Achievements |
Although health jawbone remodeling is essential for the dental implant placement treatment process, the failure of implantation has often accompanied by the elderly and patients with bone metabolic diseases. Dedifferentiated adipose (DFAT) cells are known to be cells with MSC properties together with adipose-derived MSCs (ASCs). However, it is unclear whether jawbone using DFAT cells is efficient on cellular regenerative therapy. In present study, new bone formation was significantly promoted when fibrin gel was used in combination with DFAT cells for implant treatment. Therefore, the jawbone regeneration therapy combination with fibrin gel may lead to develop of in rapid and reliable acquisition for osseointegration during implant therapy.
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| Free Research Field |
口腔インプラント学分野
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| Academic Significance and Societal Importance of the Research Achievements |
脂肪由来の幹細胞(ASCs)が現在臨床応用されはじめているのに比較して、DFAT細胞を用いた細胞再生療法に関して研究レベルでの報告にとどまっている。また、顎骨へのインプラント埋入における細胞再生療法に関する報告はほとんどなく、さらに、間葉系幹細胞とフィフリンゲル(CGFやAFG)を使用しての細胞再生療法の研究はない。
従って、インプラント治療過程での骨増生手術時に間葉系幹細胞様特性を持つDFAT細胞使用して細胞骨再生療法によるオッセオインテグレーション獲得への効果について明らかにすることは、将来的な臨床における新規治療法を開発において非常に意義があると考えられる。
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