roteomic, metagenomic and genome-wide analyses of oral cavity of ovariectomized rats with psychological stress

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K21094
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Paudel Durga 北海道医療大学, 先端研究推進センター, 助教 (20910590)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: psychology / stress / oral cavity / saliva / oral microbiota / amitriptyline / RNA seq / salivary glands

Outline of Final Research Achievements

The study aimed to explore if psychological stress and postmenopausal conditions can affect the gene expression, protein expression, and microbiota in the oral cavity including saliva and salivary glands. We demonstrated two important findings: 1) The drugs used to relieve or treat psychological stress can affect the microbiota in the oral cavity. 2) Psychological stress affects gene expression and protein expression in salivary glands, which can alter salivary rate or flow. These findings have been published in two different international journals as a research paper.

Free Research Field

Psychosomatic Dentistry

Academic Significance and Societal Importance of the Research Achievements

The findings of our study will aid in understanding the effect of psychological stress and drugs used to relieve psychological stress on the oral cavity in gene expression, protein expression, and microbiota.