An exploratory study of the causes of trash house in frontotemporal dementia

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K21189
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Osaka University
• Principal Investigator: Taomoto Daiki 大阪大学, 医学部附属病院, 医員 (60906725)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: 前頭側頭型認知症 / 意味性認知症 / 進行性非流暢性失語 / ためこみ症 / ごみ屋敷 / frontotemporal dementia / hoarding disorder / trash house

Outline of Final Research Achievements

Studies 1 and 2: The Japanese version of the CDR plus NACC FTLD was developed. The reliability, validity, and responsiveness of the Japanese version of the CDR plus NACC FTLD were assessed in 29 patients with frontotemporal dementia (FTD) and 21 patients with Alzheimer's dementia (AD), and good reliability, validity, and responsiveness were confirmed (Taomoto D, et al. 2023).
Study 3: The Clutter Image Rating (CIR), a rating scale for hoarding symptoms, was also assessed; the CIR for FTD and AD was 1.78 (0.99) (mean (SD)) and 1.63 (0.86), both below the cut-off of 4, with no significant differences between the two groups. A possible reason for this is that this study included patients with a caregiver or who were hospitalised.

Free Research Field

老年精神医学、神経心理学

Academic Significance and Societal Importance of the Research Achievements

日本語版CDR plus NACC FTLDの有用性を確認できたことにより、今後の本邦でのFTDを対象とした観察研究や治験で日本語版CDR plus NACC FTLDを活用することが可能となった。FTDにおけるごみ屋敷では生活環境が影響していることが示唆されたため、今後は独居や同居だが家族が困難を抱えている症例などを組み込んだ研究が重要と考えられた。